Chihuahua: inherited diseases and health

Updated 2026-09-30 · 3 sources

Based on: OMIA (University of Sydney), Science for Animal Welfare (UFAW), Wikidata

Breed health

The inherited conditions below have been documented in this breed in published research. That does not mean your dog has them or will get them – but it helps to know the names when you talk to a breeder or a vet.

Conditions this breed is prone to

Veterinary charities list this breed as more likely than others to get these conditions. Read the signs and what to do:

Chihuahua and chocolate: how much is dangerous?

Typical adult weight: 1.5–2.5 kg. Grams of chocolate at which signs can start (20 mg/kg) and at which severe signs are reported (40 mg/kg):

Dog weightMilkDark 70–85%Baking / unsweetened
1.5 kg15 g signs
30 g severe
3.8 g signs
7.5 g severe
2.1 g signs
4.3 g severe
2.5 kg25 g signs
50 g severe
6.2 g signs
12 g severe
3.6 g signs
7.1 g severe

Based on published doses: signs from about 20 mg/kg, severe signs from 40 mg/kg (US FDA, Cortinovis & Caloni 2016, Swedish Poison Information Centre). An estimate, not a diagnosis.

Check the exact amount with the chocolate calculator →

Inherited conditions documented in the breed

Conditions documented: 22

A gene variant is known for 17 of the conditions below, so a DNA test may exist. Ask your vet or the breed club.

ConditionBody systemInheritanceGene variant known
Alexander disease[1]Nervous systemAutosomal dominantYes
Amelia, RSPO2-related[1]Skeleton (incl. short stature & teeth)Probably autosomal recessiveNo
Chiari malformation Type I with syringomyelia[1]Nervous systemMultifactorialNo
classical Ehlers-Danlos syndrome (cEDS), COL5A2-related[1]Integument (skin)Autosomal dominantYes
Coat colour, dilution, MLPH-related[1]PigmentationAutosomal recessiveYes
Coat colour, merle[1]PigmentationAutosomal incomplete dominantYes
Dwarfism, growth-hormone deficiency[1]Skeleton (incl. short stature & teeth)–Yes
Hydrocephalus[2]–––
Hyperkeratosis, epidermolytic[1]Integument (skin)AutosomalYes
Ichthyosis, ALOXE3-related[1]Integument (skin)Probably autosomal recessiveYes
Ichthyosis, non-epidermolytic, SDR9C7-related[1]Integument (skin)–Yes
Intervertebral disc disease, predisposition to[1]Skeleton (incl. short stature & teeth)Autosomal dominantYes
Leigh syndrome, NDUFS7-related[1]Nervous systemAutosomal recessiveYes
Meningoencephalitis[1]Nervous systemMultifactorialNo
Methaemoglobinaemia, CYB5R3-related[1]Haematopoietic systemAutosomal recessiveYes
Myoclonus epilepsy of Lafora[1]Behaviour / neurologicalAutosomal recessiveYes
Neuronal ceroid lipofuscinosis, 7[1]Lysosomal storage diseaseAutosomal recessiveYes
Progressive rod-cone degeneration, PRCD-related[1]Vision / eyeAutosomal recessiveYes
Pyruvate kinase deficiency of erythrocyte[1]Homeostasis / metabolismAutosomal recessiveYes
Spinal dysraphism[1]Skeleton (incl. short stature & teeth)Autosomal recessiveYes
Transitional lumbosacral vertebrae[1]Skeleton (incl. short stature & teeth)MultifactorialNo
Verrucous epidermal keratinocytic nevi[1]Integument (skin)X-linked incomplete dominantYes

What this list means

  • “Documented in the breed” means at least one published case or study – it says nothing about how common the condition is.
  • Many of these conditions are rare. A responsible breeder can tell you which health tests the parents have had.
  • Where the gene variant is known, a DNA test may exist – ask your vet or the breed club.
  • If your pet shows signs of illness, contact your vet. This page cannot tell you whether your pet is ill.

About the breed

Origin
Mexico
Weight
1.5–2.5 kg
FCI number
218
[3]
If your pet is struggling to breathe, has collapsed, is having a seizure or can't stand up: go to the nearest vet now.

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Sources

  1. OMIA (University of Sydney)
  2. Science for Animal Welfare (UFAW)
  3. Wikidata

How this page was made: the list is taken directly from the sources below; nothing on it was written by AI. Names of conditions may be machine-translated. It is information, not a diagnosis. How we write our pages

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